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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 43 European ancestry cases, 10,701 European ancestry controls.
The effect
Each copy of the G allele carried 18.11 times the odds of Carbamazepine-induced serious cutaneous adverse reaction (95% confidence interval 8.03-40.88); p = 2 × 10−12.
How common The G allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.
What each result means
A/ANo copy of the version the research linked to Carbamazepine-induced serious cutaneous adverse reaction. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Carbamazepine-induced serious cutaneous adverse reaction. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Carbamazepine-induced serious cutaneous adverse reaction. That is the strongest link of the three results. A link in a study is not a diagnosis.
Clinical pharmacology and therapeutics · 2019 · PMID 31066027 · open access
Questions about rs192543598
What is rs192543598?
rs192543598 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with carbamazepine-induced serious cutaneous adverse reaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs192543598 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs192543598 come from?
GWAS Catalog, Clinical pharmacology and therapeutics 2019, PMID:31066027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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