Sensitive

Large artery stroke (MTAG)

FLT1 · rs1924981

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 6,399 European ancestry cases, 1,234,808 European ancestry controls.

The effect Each copy of the T allele carried 1.05 times the odds of Large artery stroke (MTAG) (95% confidence interval 1.03-1.07); p = 2 × 10⁻⁸.

How common The T allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 13, band 13q12.3 — in an intron of FLT1.

What each result means

C/C No copy of the version the research linked to Large artery stroke (MTAG). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Large artery stroke (MTAG). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Large artery stroke (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK

and 175 more — show all

Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Shimizu A, Smith NL, Sloane KL, Sutoh Y, Sun YV, Tanno K, Tiedt S, Tatlisumak T, Torres-Aguila NP, Tiwari HK, Trégouët DA, Trompet S, Tuladhar AM, Tybjærg-Hansen A, van Vugt M, Vibo R, Verma SS, Wiggins KL, Wennberg P, Woo D, Wilson PWF, Xu H, Yang Q, Yoon K, Millwood IY, Gieger C, Ninomiya T, Grabe HJ, Jukema JW, Rissanen IL, Strbian D, Kim YJ, Chen PH, Mayerhofer E, Howson JMM, Irvin MR, Adams H, Wassertheil-Smoller S, Christensen K, Ikram MA, Rundek T, Worrall BB, Lathrop GM, Riaz M, Simonsick EM, Kõrv J, França PHC, Zand R, Prasad K, Frikke-Schmidt R, de Leeuw FE, Liman T, Haeusler KG, Ruigrok YM, Heuschmann PU, Longstreth WT, Jung KJ, Bastarache L, Paré G, Damrauer SM, Chasman DI, Rotter JI, Anderson CD, Zwart JA, Niiranen TJ, Fornage M, Liaw YP, Seshadri S, Fernández-Cadenas I, Walters RG, Ruff CT, Owolabi MO, Huffman JE, Milani L, Kamatani Y, Dichgans M, Debette S

COMPASS Consortium · INVENT Consortium · Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group · Estonian Biobank · PRECISE4Q Consortium · FinnGen Consortium · NINDS Stroke Genetics Network (SiGN) · MEGASTROKE Consortium · SIREN Consortium · China Kadoorie Biobank Collaborative Group · VA Million Veteran Program · International Stroke Genetics Consortium (ISGC) · Biobank Japan · CHARGE Consortium · GIGASTROKE Consortium

Nature · 2022 · PMID 36180795 · open access

Questions about rs1924981

What is rs1924981?

rs1924981 is a single position in the genome, in or near the FLT1 gene. Published research associates it with large artery stroke (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1924981 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1924981 come from?

GWAS Catalog, Nature 2022, PMID:36180795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Large artery stroke (MTAG) (rs1924981). MyGeneLog™. https://www.mygenelog.com/variants/rs1924981

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