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Who was studied 628 European ancestry cases, 7,352 European ancestry controls.
The effect
Each copy of the T allele carried 2.35 times the odds of Classic bladder exstrophy (95% confidence interval 1.82-3.03); p = 7 × 10−11.
Where it sits Chromosome 1, band 1p31.1 — in an intron of ADGRL2.
What each result means
C/CNo copy of the version the research linked to Classic bladder exstrophy. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Classic bladder exstrophy. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Classic bladder exstrophy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2022 · PMID 36352089 · open access
Questions about rs1924557
What is rs1924557?
rs1924557 is a single position in the genome, in or near the ADGRL2 gene. Published research associates it with classic bladder exstrophy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1924557 linked to?
On MyGeneLog this position is linked to Classic Bladder Exstrophy. The research behind each link, and its sources, are set out on that condition page.
Does having rs1924557 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1924557 come from?
GWAS Catalog, Communications biology 2022, PMID:36352089. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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