Alzheimer's disease or family history of Alzheimer's disease
ASPSCR1 · rs192423465
0 221212214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others14Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,559 Hispanic cases, 5,908 Hispanic controls, 996 African ancestry cases, 1,134 African ancestry controls, 1,100 Admixed-American ancestry cases, 31,755 Admixed-American ancestry controls, 7,077 European ancestry cases, 65 European ancestry controls, 285 East or South Asian cases, 2,266 East or South Asian controls, 21 Middle-Eastern ancestry cases, 94 Middle-Eastern ancestry controls.
The effect
Each copy of the T allele carried 3.30 times the odds of Alzheimer's disease or family history of Alzheimer's disease (95% confidence interval 2.2-5.0); p = 2 × 10−8.
Where it sits Chromosome 17, band 17q25.3 — in an intron of ASPSCR1.
What each result means
C/CNo copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 41755704 · open access
Questions about rs192423465
What is rs192423465?
rs192423465 is a single position in the genome, in or near the ASPSCR1 gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs192423465 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs192423465 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs192423465 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:41755704. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 221212214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others14Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Alzheimer's disease or family history of Alzheimer's disease (rs192423465). MyGeneLog™. https://www.mygenelog.com/variants/rs192423465