Standard
Pulse pressure
near HMGB3P18 · rs1919865
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals; replicated in 299,024 European ancestry individuals, 17,277 individuals.
The effect
Each copy of the T allele shifted the measure 0.317 mmHg higher (95% confidence interval 0.25-0.38); p = 4 × 10−20.
How common The T allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 6, band 6q22.31 — between genes, 58.3 kb from HMGB3P18.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Pulse pressure — no copies of the reported risk allele.
A/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulse pressure.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulse pressure compared to the general population.
Source
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
Giri A,
Hellwege JN,
Keaton JM,
Park J,
Qiu C,
Warren HR,
Torstenson ES,
Kovesdy CP,
Sun YV,
Wilson OD,
Robinson-Cohen C,
Roumie CL
and 86 more — show all
Chung CP,
Birdwell KA,
Damrauer SM,
DuVall SL,
Klarin D,
Cho K,
Wang Y,
Evangelou E,
Cabrera CP,
Wain LV,
Shrestha R,
Mautz BS,
Akwo EA,
Sargurupremraj M,
Debette S,
Boehnke M,
Scott LJ,
Luan J,
Zhao JH,
Willems SM,
Thériault S,
Shah N,
Oldmeadow C,
Almgren P,
Li-Gao R,
Verweij N,
Boutin TS,
Mangino M,
Ntalla I,
Feofanova E,
Surendran P,
Cook JP,
Karthikeyan S,
Lahrouchi N,
Liu C,
Sepúlveda N,
Richardson TG,
Kraja A,
Amouyel P,
Farrall M,
Poulter NR,
Laakso M,
Zeggini E,
Sever P,
Scott RA,
Langenberg C,
Wareham NJ,
Conen D,
Palmer CNA,
Attia J,
Chasman DI,
Ridker PM,
Melander O,
Mook-Kanamori DO,
Harst PV,
Cucca F,
Schlessinger D,
Hayward C,
Spector TD,
Jarvelin MR,
Hennig BJ,
Timpson NJ,
Wei WQ,
Smith JC,
Xu Y,
Matheny ME,
Siew EE,
Lindgren C,
Herzig KH,
Dedoussis G,
Denny JC,
Psaty BM,
Howson JMM,
Munroe PB,
Newton-Cheh C,
Caulfield MJ,
Elliott P,
Gaziano JM,
Concato J,
Wilson PWF,
Tsao PS,
Velez Edwards DR,
Susztak K,
O'Donnell CJ,
Hung AM,
Edwards TL
Nature genetics · 2019 · PMID 30578418 · open access
Questions about rs1919865
What is rs1919865?
rs1919865 is a single position in the genome, in or near the near HMGB3P18 gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1919865 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1919865 come from?
GWAS Catalog, Nature genetics 2019, PMID:30578418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pulse pressure (rs1919865). MyGeneLog™. https://www.mygenelog.com/variants/rs1919865
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