Standard
Highest math class taken (MTAG)
PFKFB4 · rs191903670
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 811,539 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0374 higher (95% confidence interval 0.026-0.049); p = 2 × 10−10.
How common The A allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 3, band 3p21.31 — in an intron of PFKFB4.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Highest math class taken (MTAG) compared to the general population.
A/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Highest math class taken (MTAG).
T/T
Published research associates this genotype with typical/baseline likelihood of Highest math class taken (MTAG) — no copies of the reported risk allele.
Source
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Lee JJ,
Wedow R,
Okbay A,
Kong E,
Maghzian O,
Zacher M,
Nguyen-Viet TA,
Bowers P,
Sidorenko J,
Karlsson Linnér R,
Fontana MA,
Kundu T
and 65 more — show all
Lee C,
Li H,
Li R,
Royer R,
Timshel PN,
Walters RK,
Willoughby EA,
Yengo L,
Alver M,
Bao Y,
Clark DW,
Day FR,
Furlotte NA,
Joshi PK,
Kemper KE,
Kleinman A,
Langenberg C,
Mägi R,
Trampush JW,
Verma SS,
Wu Y,
Lam M,
Zhao JH,
Zheng Z,
Boardman JD,
Campbell H,
Freese J,
Harris KM,
Hayward C,
Herd P,
Kumari M,
Lencz T,
Luan J,
Malhotra AK,
Metspalu A,
Milani L,
Ong KK,
Perry JRB,
Porteous DJ,
Ritchie MD,
Smart MC,
Smith BH,
Tung JY,
Wareham NJ,
Wilson JF,
Beauchamp JP,
Conley DC,
Esko T,
Lehrer SF,
Magnusson PKE,
Oskarsson S,
Pers TH,
Robinson MR,
Thom K,
Watson C,
Chabris CF,
Meyer MN,
Laibson DI,
Yang J,
Johannesson M,
Koellinger PD,
Turley P,
Visscher PM,
Benjamin DJ,
Cesarini D
Nature genetics · 2018 · PMID 30038396
Questions about rs191903670
What is rs191903670?
rs191903670 is a single position in the genome, in or near the PFKFB4 gene. Published research associates it with highest math class taken (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs191903670 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs191903670 come from?
GWAS Catalog, Nature genetics 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Highest math class taken (MTAG) (rs191903670). MyGeneLog™. https://www.mygenelog.com/variants/rs191903670
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