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Platelet count

TLE4 · rs191751273

Where this position leads

Condition: Blood Cell Counts

rs191751273 Condition: Blood Cell Counts Blood Cell Counts Condition rs191751273 rs191751273 TLE4

What the study found

Who was studied 542,827 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.192 SD unit higher (95% confidence interval 0.15-0.24); p = 5 × 10−16.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 9, band 9q21.31 — in an intron of TLE4.

What each result means

G/G No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs191751273

What is rs191751273?

rs191751273 is a single position in the genome, in or near the TLE4 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs191751273 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs191751273 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs191751273 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Platelet count (rs191751273). MyGeneLog™. https://www.mygenelog.com/variants/rs191751273

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