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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.476 higher (95% confidence interval 0.37-0.58); p = 3 × 10−22.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.
What each result means
C/CNo copy of the version the research linked to FCRLB protein levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to FCRLB protein levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to FCRLB protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs191648462
What is rs191648462?
rs191648462 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with fcrlb protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs191648462 affect how medicines work?
NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs191648462 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs191648462 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
FCRLB protein levels (rs191648462). MyGeneLog™. https://www.mygenelog.com/variants/rs191648462