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ICAM2 protein levels

ST3GAL6-AS1 · rs191600187

Where this position leads

Condition: Celiac Disease

rs191600187 Condition: Celiac Disease Celiac Disease Condition rs191600187 rs191600187 ST3GAL6-AS1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.284 lower (95% confidence interval 0.19-0.38); p = 1 × 10−12.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 3, band 3q12.1 — in an intron of ST3GAL6-AS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of ICAM2 protein levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with ICAM2 protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of ICAM2 protein levels compared to the general population.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs191600187

What is rs191600187?

rs191600187 is a single position in the genome, in or near the ST3GAL6-AS1 gene. Published research associates it with icam2 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs191600187 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs191600187 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs191600187 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

ICAM2 protein levels (rs191600187). MyGeneLog™. https://www.mygenelog.com/variants/rs191600187

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