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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,642 European ancestry women.
The effect
Each copy of the C allele shifted the measure 0.398 lower (95% confidence interval 0.29-0.51); p = 4 × 10−13.
Where it sits Chromosome 17, band 17p13.2 — between genes, 122 kb from NLRP1.
What each result means
C/CTwo copies of the version the research linked to Sphingomyelin (d40:1) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Sphingomyelin (d40:1) levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Sphingomyelin (d40:1) levels. This is the starting point the study compared everyone against.
Journal of the American Heart Association · 2022 · PMID 36193934 · open access
Questions about rs191290403
What is rs191290403?
rs191290403 is a single position in the genome, in or near the near NLRP1 gene. Published research associates it with sphingomyelin (d40:1) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs191290403 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs191290403 come from?
GWAS Catalog, Journal of the American Heart Association 2022, PMID:36193934. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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