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Who was studied 801 African American or Afro-Caribbean cases, 120,641 African American or Afro-Caribbean controls, 4,713 European ancestry cases, 444,093 European ancestry controls, 441 Hispanic or Latin American cases, 59,228 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 3.56 higher (95% confidence interval -17.7658-24.8838); p = 9 × 10−14.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 3, band 3p25.3 — in an intron of SLC6A1.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease (PheCode 290.11). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease (PheCode 290.11). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease (PheCode 290.11). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs191177039
What is rs191177039?
rs191177039 is a single position in the genome, in or near the SLC6A1 gene. Published research associates it with alzheimer's disease (phecode 290.11). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs191177039 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs191177039 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs191177039 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11128Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others8Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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