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Small cell lung carcinoma

near KRT18P1 · rs191133092

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,267 European ancestry cases, 23,173 European ancestry controls, 99 East Asian ancestry cases, 5,372 East Asian ancestry controls, 116 African American cases, 3,774 African American controls; replicated in 1,268 European ancestry cases, 365,282 European ancestry controls, 29 African American cases, 560 African American controls.

The effect Each copy of the T allele shifted the measure 1.8 higher (95% confidence interval 1.19-2.41); p = 7 × 10−9.

Where it sits Chromosome 6, band 6p22.1 — between genes, 3.9 kb from KRT18P1.

What each result means

A/A No copy of the version the research linked to Small cell lung carcinoma. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Small cell lung carcinoma. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Small cell lung carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z
and 73 more — show all
Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CI
Nature genetics · 2022 · PMID 35915169

Questions about rs191133092

What is rs191133092?

rs191133092 is a single position in the genome, in or near the near KRT18P1 gene. Published research associates it with small cell lung carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs191133092 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs191133092 come from?

GWAS Catalog, Nature genetics 2022, PMID:35915169. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Small cell lung carcinoma (rs191133092). MyGeneLog™. https://www.mygenelog.com/variants/rs191133092

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