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Restless legs syndrome (PheCode 327.71)

near LINC01304 · rs1908245

Where this position leads

Condition: Restless Legs Syndrome

rs1908245 Condition: Restless Legs Syndrome Restless Legs Syndrome Condition rs1908245 rs1908245 near LINC013…

What the study found

Who was studied 1,303 African American or Afro-Caribbean cases, 119,437 African American or Afro-Caribbean controls, 15,475 European ancestry cases, 428,445 European ancestry controls, 1,148 Hispanic or Latin American cases, 57,993 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.0991 higher (95% confidence interval 0.073-0.125); p = 2 × 10−16.

How common The A allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 2, band 2p25.3 — between genes, 17.6 kb from LINC01304.

What each result means

A/A Two copies of the version the research linked to Restless legs syndrome (PheCode 327.71). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Restless legs syndrome (PheCode 327.71). That is a smaller link than two copies.
G/G No copy of the version the research linked to Restless legs syndrome (PheCode 327.71). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs1908245

What is rs1908245?

rs1908245 is a single position in the genome, in or near the near LINC01304 gene. Published research associates it with restless legs syndrome (phecode 327.71). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1908245 linked to?

On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs1908245 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1908245 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Restless legs syndrome (PheCode 327.71) (rs1908245). MyGeneLog™. https://www.mygenelog.com/variants/rs1908245

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