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Hereditary pheochromocytoma and paraganglioma

SDHA · rs189989110

Where this position leads

Condition: Glioma

rs189989110 Condition: Glioma Glioma Condition rs189989110 rs189989110 SDHA

Strength of the evidence

There is no record yet to score this position by (a ClinVar disease classification or a genome-wide significant study). That is not the same as weak evidence.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Conflicting classifications of pathogenicity for Hereditary pheochromocytoma and paraganglioma, Mitochondrial complex II deficiency, nuclear type 1, Leigh syndrome; criteria provided, conflicting classifications (1 of 4 stars, 1 submitter), last evaluated 2017-04-27. ClinVar record 905347 NM_004168.4(SDHA):c.*249T>C

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version labs disagree about for Hereditary pheochromocytoma and paraganglioma: in ClinVar, some labs call it disease-causing and others do not. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000905347, criteria provided, conflicting classifications)
C/T One copy of the version labs disagree about for Hereditary pheochromocytoma and paraganglioma: in ClinVar, some labs call it disease-causing and others do not, so what one copy means is not settled. A genetic counsellor can look at the separate records. (ClinVar VCV000905347, criteria provided, conflicting classifications)
T/T No copy of the version labs disagree about for Hereditary pheochromocytoma and paraganglioma: in ClinVar, some labs call it disease-causing and others do not. This is the usual result. (ClinVar VCV000905347, criteria provided, conflicting classifications)

Source: ClinVar VCV000905347, criteria provided, conflicting classifications

Questions about rs189989110

What is rs189989110?

rs189989110 is a single position in the genome, in or near the SDHA gene. Published research associates it with hereditary pheochromocytoma and paraganglioma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs189989110 linked to?

On MyGeneLog this position is linked to Glioma. The research behind each link, and its sources, are set out on that condition page.

Does having rs189989110 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs189989110 come from?

ClinVar VCV000905347, criteria provided, conflicting classifications. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Hereditary pheochromocytoma and paraganglioma (rs189989110). MyGeneLog™. https://www.mygenelog.com/variants/rs189989110

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