Standard
Personal history of allergy to medicinal agents (PheCode 977)
NRROS · rs189974384
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 304 African American or Afro-Caribbean cases, 120,775 African American or Afro-Caribbean controls, 535 European ancestry cases, 448,351 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 3.05 lower (95% confidence interval 3.02-3.07); p = 1 × 10−12.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 3, band 3q29 — in an intron of NRROS.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Personal history of allergy to medicinal agents (PheCode 977) compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Personal history of allergy to medicinal agents (PheCode 977).
G/G
Published research associates this genotype with typical/baseline likelihood of Personal history of allergy to medicinal agents (PheCode 977) — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A,
Huffman JE,
Rodriguez A,
Conery M,
Liu M,
Ho YL,
Kim Y,
Heise DA,
Guare L,
Panickan VA,
Garcon H,
Linares F
and 59 more — show all
Costa L,
Goethert I,
Tipton R,
Honerlaw J,
Davies L,
Whitbourne S,
Cohen J,
Posner DC,
Sangar R,
Murray M,
Wang X,
Dochtermann DR,
Devineni P,
Shi Y,
Nandi TN,
Assimes TL,
Brunette CA,
Carroll RJ,
Clifford R,
Duvall S,
Gelernter J,
Hung A,
Iyengar SK,
Joseph J,
Kember R,
Kranzler H,
Kripke CM,
Levey D,
Luoh SW,
Merritt VC,
Overstreet C,
Deak JD,
Grant SFA,
Polimanti R,
Roussos P,
Shakt G,
Sun YV,
Tsao N,
Venkatesh S,
Voloudakis G,
Justice A,
Begoli E,
Ramoni R,
Tourassi G,
Pyarajan S,
Tsao P,
O'Donnell CJ,
Muralidhar S,
Moser J,
Casas JP,
Bick AG,
Zhou W,
Cai T,
Voight BF,
Cho K,
Gaziano JM,
Madduri RK,
Damrauer S,
Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs189974384
What is rs189974384?
rs189974384 is a single position in the genome, in or near the NRROS gene. Published research associates it with personal history of allergy to medicinal agents (phecode 977). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs189974384 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs189974384 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Personal history of allergy to medicinal agents (PheCode 977) (rs189974384). MyGeneLog™. https://www.mygenelog.com/variants/rs189974384
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