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C-C motif chemokine 7 (analyte X4886.3) levels

near CCL8 · rs1897351

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,506 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.414 lower (95% confidence interval 0.35-0.48); p = 1 × 10−38.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 17, band 17q12 — between genes, 6.4 kb from CCL8.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of C-C motif chemokine 7 (analyte X4886.3) levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with C-C motif chemokine 7 (analyte X4886.3) levels.
G/G Published research associates this genotype with typical/baseline likelihood of C-C motif chemokine 7 (analyte X4886.3) levels — no copies of the reported risk allele.
Source
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P
and 28 more — show all
Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M, Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C
Dominantly Inherited Alzheimer Network (DIAN) · Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nature genetics · 2024 · PMID 39528825

Questions about rs1897351

What is rs1897351?

rs1897351 is a single position in the genome, in or near the near CCL8 gene. Published research associates it with c-c motif chemokine 7 (analyte x4886.3) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1897351 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1897351 come from?

GWAS Catalog, Nature genetics 2024, PMID:39528825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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C-C motif chemokine 7 (analyte X4886.3) levels (rs1897351). MyGeneLog™. https://www.mygenelog.com/variants/rs1897351

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