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Low affinity immunoglobulin gamma Fc region receptor II-b levels

NOS1AP · rs189676321

Where this position leads

Drug: QT-prolonging medicines

rs189676321 Drug: QT-prolonging medicines QT-prolonging medicines Drug rs189676321 rs189676321 NOS1AP

What the study found

Who was studied 2,935 Qatari ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.481 higher (95% confidence interval 0.37-0.59); p = 1 × 10−18.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.

What each result means

A/A Two copies of the version the research linked to Low affinity immunoglobulin gamma Fc region receptor II-b levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Low affinity immunoglobulin gamma Fc region receptor II-b levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Low affinity immunoglobulin gamma Fc region receptor II-b levels. This is the starting point the study compared everyone against.
Source

Questions about rs189676321

What is rs189676321?

rs189676321 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with low affinity immunoglobulin gamma fc region receptor ii-b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs189676321 affect how medicines work?

NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs189676321 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs189676321 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36168886. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Low affinity immunoglobulin gamma Fc region receptor II-b levels (rs189676321). MyGeneLog™. https://www.mygenelog.com/variants/rs189676321

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