Standard

Gout (PheCode 274.1)

BICC1 · rs1896246

Where this position leads

Condition: Gout

rs1896246 Condition: Gout Gout Condition rs1896246 rs1896246 BICC1

What the study found

Who was studied 6,538 African American or Afro-Caribbean cases, 48,967 African American or Afro-Caribbean controls, 2,151 Hispanic or Latin American cases, 27,163 Hispanic or Latin American controls, 739 East Asian ancestry cases, 2,808 East Asian ancestry controls, 31,493 European ancestry cases, 284,175 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0734 higher (95% confidence interval 0.056-0.091); p = 3 × 10−18.

How common The A allele had a frequency of about 51% in the people studied.

Where it sits Chromosome 10, band 10q21.1 — in an intron of BICC1.

What each result means

A/A Two copies of the version the research linked to Gout (PheCode 274.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Gout (PheCode 274.1). That is a smaller link than two copies.
G/G No copy of the version the research linked to Gout (PheCode 274.1). This is the starting point the study compared everyone against.
Source

Questions about rs1896246

What is rs1896246?

rs1896246 is a single position in the genome, in or near the BICC1 gene. Published research associates it with gout (phecode 274.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1896246 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs1896246 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1896246 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gout (PheCode 274.1) (rs1896246). MyGeneLog™. https://www.mygenelog.com/variants/rs1896246

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