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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.107 higher (95% confidence interval 0.076-0.138); p = 1 × 10−12.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — between genes, 2.7 kb from LNC-RHL1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Apolipoprotein A levels (UKB data field 30630) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Apolipoprotein A levels (UKB data field 30630).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Apolipoprotein A levels (UKB data field 30630) compared to the general population.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs189391949
What is rs189391949?
rs189391949 is a single position in the genome, in or near the near LNC-RHL1 gene. Published research associates it with apolipoprotein a levels (ukb data field 30630). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs189391949 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs189391949 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs189391949 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 61113Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon1Apple0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Apolipoprotein A levels (UKB data field 30630) (rs189391949). MyGeneLog™. https://www.mygenelog.com/variants/rs189391949