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MMP12 protein levels

near MMP13 · rs1892971

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.189 higher (95% confidence interval 0.18-0.2); p = 2 × 10−234.

How common The A allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 11, band 11q22.2 — between genes, 18.1 kb from MMP13.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of MMP12 protein levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with MMP12 protein levels.
G/G Published research associates this genotype with typical/baseline likelihood of MMP12 protein levels — no copies of the reported risk allele.
Source

Questions about rs1892971

What is rs1892971?

rs1892971 is a single position in the genome, in or near the near MMP13 gene. Published research associates it with mmp12 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1892971 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1892971 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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MMP12 protein levels (rs1892971). MyGeneLog™. https://www.mygenelog.com/variants/rs1892971

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