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Chitinase-3-like protein 1 levels

PPFIA4 · rs1890414

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,935 Qatari ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.253 higher (95% confidence interval 0.2-0.31); p = 3 × 10⁻²⁰.

How common The T allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — in an intron of PPFIA4.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Chitinase-3-like protein 1 levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chitinase-3-like protein 1 levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chitinase-3-like protein 1 levels compared to the general population.

Source

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

Thareja G, Belkadi A, Arnold M, Albagha OME, Graumann J, Schmidt F, Grallert H, Peters A, Gieger C, Consortium TQGPR, Suhre K

Human molecular genetics · 2023 · PMID 36168886 · open access

Questions about rs1890414

What is rs1890414?

rs1890414 is a single position in the genome, in or near the PPFIA4 gene. Published research associates it with chitinase-3-like protein 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1890414 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1890414 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36168886. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chitinase-3-like protein 1 levels (rs1890414). MyGeneLog™. https://www.mygenelog.com/variants/rs1890414

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