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Who was studied 380,287 European ancestry individuals; replicated in 4,089 European ancestry cases, 11,901 European ancestry controls, 44,848 cases, 1,571,864 controls.
The effect
Each copy of the C allele shifted the measure 0.0843 higher (95% confidence interval 0.07-0.099); p = 7 × 10−31.
How common The C allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 9, band 9q31.2 — between genes, 9.7 kb from RPS15AP27.
What each result means
C/CTwo copies of the version the research linked to Cutaneous melanoma (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Cutaneous melanoma (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cutaneous melanoma (MTAG). This is the starting point the study compared everyone against.
The Journal of investigative dermatology · 2022 · PMID 34813871
Questions about rs1888621
What is rs1888621?
rs1888621 is a single position in the genome, in or near the near RPS15AP27 gene. Published research associates it with cutaneous melanoma (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1888621 linked to?
On MyGeneLog this position is linked to Cutaneous Malignant Melanoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1888621 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1888621 come from?
GWAS Catalog, The Journal of investigative dermatology 2022, PMID:34813871. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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