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Who was studied 309 African American or Afro-Caribbean cases, 55,196 African American or Afro-Caribbean controls, 1,102 European ancestry cases, 314,566 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 2.76 lower (95% confidence interval 2.73-2.8); p = 2 × 10−13.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 2, band 2p23.3 — a missense change in ITSN2.
What ClinVar records
ClassificationUncertain significance; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2024-02-12.
ClinVar record 2352952NM_006277.3(ITSN2):c.4472C>T (p.Thr1491Met)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Biological Father: Schizophrenia. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Biological Father: Schizophrenia. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Biological Father: Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs188839242
What is rs188839242?
rs188839242 is a single position in the genome, in or near the ITSN2 gene. Published research associates it with biological father: schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs188839242 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs188839242 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs188839242 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 10226Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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