Sensitive

Uterine leiomyoma or ER negative breast cancer (pleiotropy)

near DDX10 · rs188691509

Where this position leads

Condition: Breast Cancer

rs188691509 Condition: Breast Cancer Breast Cancer Condition rs188691509 rs188691509 near DDX10

What the study found

Who was studied 35,474 European ancestry UL cases, 21,468 European ancestry ER-ve BC cases, 373,479 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 6 × 10−9.

Where it sits Chromosome 11, band 11q22.3 — between genes, 24.9 kb from DDX10.

What each result means

A/A Two copies of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs188691509

What is rs188691509?

rs188691509 is a single position in the genome, in or near the near DDX10 gene. Published research associates it with uterine leiomyoma or er negative breast cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs188691509 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs188691509 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs188691509 come from?

GWAS Catalog, American journal of human genetics 2022, PMID:35803233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine leiomyoma or ER negative breast cancer (pleiotropy) (rs188691509). MyGeneLog™. https://www.mygenelog.com/variants/rs188691509

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