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SARS-CoV-2 infection

FOXP4-AS1 · rs1886814

What the study found

Who was studied 2,544 African ancestry cases, 31,176 African ancestry controls, 700 Middle Eastern ancestry cases, 13,360 Middle Eastern ancestry controls, 1,495 East Asian ancestry cases, 15,499 East Asian ancestry controls, 38,984 European ancestry cases, 1,644,784 European ancestry controls, 1,688 South Asian ancestry cases, 42,016 South Asian ancestry controls, 4,151 Hispanic or Latin American cases, 23,371 Hispanic or Latin American controls.

The effect Each copy of the C allele carried 1.11 times the odds of SARS-CoV-2 infection (95% confidence interval 1.0673687203891646-1.1454568121291355); p = 2 × 10−8.

How common The C allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p21.1 — in an intron of FOXP4-AS1.

What each result means

A/A No copy of the version the research linked to SARS-CoV-2 infection. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to SARS-CoV-2 infection. That is a smaller link than two copies.
C/C Two copies of the version the research linked to SARS-CoV-2 infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1886814

What is rs1886814?

rs1886814 is a single position in the genome, in or near the FOXP4-AS1 gene. Published research associates it with sars-cov-2 infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1886814 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1886814 come from?

GWAS Catalog, Nature 2021, PMID:34237774. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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SARS-CoV-2 infection (rs1886814). MyGeneLog™. https://www.mygenelog.com/variants/rs1886814

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