Standard

QRS duration

KLF12 · rs1886512

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

What the study found

Who was studied 39,717 European ancestry individuals, 690 Orcadian individuals; replicated in 7,170 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.4 ms lower (95% confidence interval 0.26-0.54); p = 1 × 10⁻⁸.

How common The A allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 13, band 13q22.1 — in an intron of KLF12.

What each result means

A/A Two copies of the version the research linked to QRS duration. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to QRS duration. That is a smaller link than two copies.

T/T No copy of the version the research linked to QRS duration. This is the starting point the study compared everyone against.

Source

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Sotoodehnia N, Isaacs A, de Bakker PI, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S

and 91 more — show all

Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Köttgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo Leach I, Estrada K, Völker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Völzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, van Veldhuisen DJ, Schwienbacher C, O'Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, te Meerman G, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BH, Samani NJ, Kääb S, Arking DE

Nature genetics · 2010 · PMID 21076409 · open access

Questions about rs1886512

What is rs1886512?

rs1886512 is a single position in the genome, in or near the KLF12 gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1886512 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs1886512 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1886512 come from?

GWAS Catalog, Nat Genet 2010, PMID:21076409. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QRS duration (rs1886512). MyGeneLog™. https://www.mygenelog.com/variants/rs1886512

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