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Stress fracture (PheCode 743.4)

near LINC01435 · rs188617869

What the study found

Who was studied 264 African American or Afro-Caribbean cases, 121,147 African American or Afro-Caribbean controls, 1,305 European ancestry cases, 447,373 European ancestry controls.

The effect Each copy of the G allele shifted the measure 2.82 lower (95% confidence interval 2.79-2.85); p = 1 × 10−12.

How common The G allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 10, band 10q25.1 — between genes, 35.2 kb from LINC01435.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Stress fracture (PheCode 743.4) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Stress fracture (PheCode 743.4).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Stress fracture (PheCode 743.4) compared to the general population.
Source

Questions about rs188617869

What is rs188617869?

rs188617869 is a single position in the genome, in or near the near LINC01435 gene. Published research associates it with stress fracture (phecode 743.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs188617869 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs188617869 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Stress fracture (PheCode 743.4) (rs188617869). MyGeneLog™. https://www.mygenelog.com/variants/rs188617869

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