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Atrial fibrillation

MICU1 · rs188502675

Where this position leads

What the study found

Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0641 lower (95% confidence interval 0.044-0.084); p = 2 × 10⁻¹⁰.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 10, band 10q22.1 — in an intron of MICU1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Atrial fibrillation — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atrial fibrillation.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atrial fibrillation compared to the general population.

Source

Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

Yuan S, Chen J, Ruan X, Li Y, Abramowitz SA, Wang L, Jiang F, Xiong Y, Levin MG, Voight BF, Gill D, Burgess S

and 5 more — show all

Åkesson A, Michaëlsson K, Li X, Damrauer SM, Larsson SC

Nature communications · 2025 · PMID 40645996 · open access

Questions about rs188502675

What is rs188502675?

rs188502675 is a single position in the genome, in or near the MICU1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs188502675 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs188502675 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs188502675 come from?

GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs188502675). MyGeneLog™. https://www.mygenelog.com/variants/rs188502675

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