Who was studied 23,699 European ancestry individuals, 1,526 whole genome sequenced European ancestry individuals, 3,273 whole exome sequenced European ancestry individuals; replicated in 16,233 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.16 higher (95% confidence interval 0.11-0.21); p = 1 × 10−9.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 2, band 2q14.2 — between genes, 8.2 kb from EN1.
What each result means
G/GPublished research associates this genotype with typical/baseline likelihood of Lumbar spine bone mineral density — no copies of the reported risk allele.
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lumbar spine bone mineral density.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lumbar spine bone mineral density compared to the general population.
rs188303909 is a single position in the genome, in or near the EN1 gene. Published research associates it with lumbar spine bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs188303909 linked to?
On MyGeneLog this position is linked to Spine Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.
Does having rs188303909 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs188303909 come from?
GWAS Catalog, Nature 2015, PMID:26367794. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.