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High density lipoprotein cholesterol levels

SIK3 · rs188287950

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 62,138 Hispanic or Latino individuals.

The effect Each copy of the C allele shifted the measure 0.242 lower (95% confidence interval 0.19-0.3); p = 4 × 10⁻⁶⁸.

How common The C allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.

What each result means

C/C Two copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.

Source

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Petty LE, Chen HH, Frankel EG, Zhu W, Downie CG, Graff M, Lin P, Sharma P, Zhang X, Scartozzi AC, Roshani R, Landman JM

and 80 more — show all

Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Sim X, Spracklen CN, Zhang W, Preuss M, Bottinger EP, Nadkarni GN, Loos RJF, Chen YI, Tan J, Ipp E, Genter P, Emery LS, Louie T, Sofer T, Stilp AM, Taylor KD, Xiang AH, Buchanan TA, Roll K, Gao C, Palmer ND, Norris JM, Wagenknecht LE, Nousome D, Varma R, McKean-Cowdin R, Guo X, Hai Y, Hsueh W, Sandow K, Parra EJ, Cruz M, Valladares-Salgado A, Wacher-Rodarte N, Rotter JI, Goodarzi MO, Rich SS, Bertoni A, Raffel LJ, Nadler JL, Kandeel FR, Duggirala R, Blangero J, Lehman DM, DeFronzo RA, Thameem F, Wang Y, Gahagan S, Blanco E, Burrows R, Huerta-Chagoya A, Florez JC, Tusie-Luna T, González-Villalpando C, Orozco L, Haiman CA, Hanis CL, Rohde R, Whitsel EA, Reiner AP, Kooperberg C, Li Y, Duan Q, Lee M, Correa-Burrows P, Fried SK, North KE, McCormick JB, Fisher-Hoch SP, Gamazon ER, Morris AP, Mercader JM, Highland HM, Below JE

DIAMANTE Hispanic/Latino Consortium · Global Hispanic Lipids Consortium

Nature communications · 2025 · PMID 40210677 · open access

Questions about rs188287950

What is rs188287950?

rs188287950 is a single position in the genome, in or near the SIK3 gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs188287950 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs188287950 come from?

GWAS Catalog, Nature communications 2025, PMID:40210677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High density lipoprotein cholesterol levels (rs188287950). MyGeneLog™. https://www.mygenelog.com/variants/rs188287950

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