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Other specified benign mammary dysplasias (PheCode 610.8)

near METAP2P1 · rs188256118

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 271 African American or Afro-Caribbean cases, 121,238 African American or Afro-Caribbean controls, 584 European ancestry cases, 449,897 European ancestry controls.

The effect Each copy of the C allele shifted the measure 5.5 lower (95% confidence interval 5.5-5.51); p = 3 × 10−13.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 2, band 2q22.3 — between genes, 139.6 kb from METAP2P1.

What each result means

C/C Two copies of the version the research linked to Other specified benign mammary dysplasias (PheCode 610.8). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Other specified benign mammary dysplasias (PheCode 610.8). That is a smaller link than two copies.
T/T No copy of the version the research linked to Other specified benign mammary dysplasias (PheCode 610.8). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs188256118

What is rs188256118?

rs188256118 is a single position in the genome, in or near the near METAP2P1 gene. Published research associates it with other specified benign mammary dysplasias (phecode 610.8). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs188256118 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs188256118 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Other specified benign mammary dysplasias (PheCode 610.8) (rs188256118). MyGeneLog™. https://www.mygenelog.com/variants/rs188256118

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