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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.278 lower (95% confidence interval 0.19-0.36); p = 5 × 10−12.
How common The C allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 6, band 6p12.1 — in an intron of HCRTR2.
What each result means
A/ANo copy of the version the research linked to GFRAL protein levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to GFRAL protein levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to GFRAL protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs188055163
What is rs188055163?
rs188055163 is a single position in the genome, in or near the HCRTR2 gene. Published research associates it with gfral protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs188055163 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs188055163 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs188055163 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
GFRAL protein levels (rs188055163). MyGeneLog™. https://www.mygenelog.com/variants/rs188055163