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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 844 European ancestry individuals (blood measurement), 123 European ancestry individuals (liver measurement), 245 acute lymphoblastic leukemia cases (blood measurement).
The effect
Each copy of the G allele shifted the measure 1.06 lower; p = 4 × 10−12.
How common The G allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 6, band 6p22.3 — between genes, 8.2 kb from Y_RNA.
What each result means
G/GTwo copies of the version the research linked to Thiopurine S-methyltransferase activity. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Thiopurine S-methyltransferase activity. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thiopurine S-methyltransferase activity. This is the starting point the study compared everyone against.
Clinical pharmacology and therapeutics · 2017 · PMID 27770449
Questions about rs187976596
What is rs187976596?
rs187976596 is a single position in the genome, in or near the near Y_RNA gene. Published research associates it with thiopurine s-methyltransferase activity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs187976596 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs187976596 come from?
GWAS Catalog, Clinical pharmacology and therapeutics 2017, PMID:27770449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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