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Clopidogrel active metabolite levels

RAD18 · rs187941554

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Clopidogrel active metabolite levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Clopidogrel active metabolite levels.
G/G Published research associates this genotype with typical/baseline likelihood of Clopidogrel active metabolite levels — no copies of the reported risk allele.
Source
Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response
Backman JD, O'Connell JR, Tanner K, Peer CJ, Figg WD, Spencer SD, Mitchell BD, Shuldiner AR, Yerges-Armstrong LM, Horenstein RB, Lewis JP
Pharmacogenetics and genomics · 2017 · PMID 28207573

Questions about rs187941554

What is rs187941554?

rs187941554 is a single position in the genome, in or near the RAD18 gene. Published research associates it with clopidogrel active metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs187941554 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs187941554 come from?

GWAS Catalog, Pharmacogenet Genomics 2017, PMID:28207573. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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