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Low density lipoprotein cholesterol levels

UGT2B25P · rs187479321

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0813 lower (95% confidence interval 0.06-0.103); p = 2 × 10−10.

How common The G allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 4, band 4q13.2 — in an intron of UGT2B25P.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Low density lipoprotein cholesterol levels — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Low density lipoprotein cholesterol levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Low density lipoprotein cholesterol levels compared to the general population.
Source

Questions about rs187479321

What is rs187479321?

rs187479321 is a single position in the genome, in or near the UGT2B25P gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs187479321 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs187479321 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Low density lipoprotein cholesterol levels (rs187479321). MyGeneLog™. https://www.mygenelog.com/variants/rs187479321

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