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Graves' disease (PheCode 242.1)

near GPR26 · rs187196172

Where this position leads

Condition: Graves' Disease

rs187196172 Condition: Graves' Disease Graves' Disease Condition rs187196172 rs187196172 near GPR26

What the study found

Who was studied 1,020 African American or Afro-Caribbean cases, 120,535 African American or Afro-Caribbean controls, 1,672 European ancestry cases, 448,997 European ancestry controls, 279 Hispanic or Latin American cases, 59,541 Hispanic or Latin American controls.

The effect Each copy of the G allele shifted the measure 4.61 lower (95% confidence interval 4.6-4.62); p = 1 × 10−11.

How common The G allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 10, band 10q26.13 — between genes, 49.7 kb from GPR26.

What each result means

A/A No copy of the version the research linked to Graves' disease (PheCode 242.1). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Graves' disease (PheCode 242.1). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Graves' disease (PheCode 242.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs187196172

What is rs187196172?

rs187196172 is a single position in the genome, in or near the near GPR26 gene. Published research associates it with graves' disease (phecode 242.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs187196172 linked to?

On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs187196172 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs187196172 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Graves' disease (PheCode 242.1) (rs187196172). MyGeneLog™. https://www.mygenelog.com/variants/rs187196172

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