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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 213 African American or Afro-Caribbean cases, 121,499 African American or Afro-Caribbean controls, 289 European ancestry cases, 450,826 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 3.02 lower (95% confidence interval 2.99-3.05); p = 4 × 10−11.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 6, band 6q22.31 — in an intron of PKIB.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypotony of eye (PheCode 360.3) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypotony of eye (PheCode 360.3).
G/GPublished research associates this genotype with typical/baseline likelihood of Hypotony of eye (PheCode 360.3) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs186699539
What is rs186699539?
rs186699539 is a single position in the genome, in or near the PKIB gene. Published research associates it with hypotony of eye (phecode 360.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs186699539 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186699539 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hypotony of eye (PheCode 360.3) (rs186699539). MyGeneLog™. https://www.mygenelog.com/variants/rs186699539