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Systolic blood pressure

near INSR · rs1864009

Where this position leads

Condition: Blood Pressure

rs1864009 Condition: Blood Pressure Blood Pressure Condition rs1864009 rs1864009 near INSR

What the study found

Who was studied 526,001 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.376 higher (95% confidence interval 0.27-0.48); p = 1 × 10−12.

Where it sits Chromosome 19, band 19p13.2 — between genes, 0.5 kb from INSR.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systolic blood pressure compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systolic blood pressure.
C/C Published research associates this genotype with typical/baseline likelihood of Systolic blood pressure — no copies of the reported risk allele.
Source
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study
Plotnikov D, Huang Y, Khawaja AP, Foster PJ, Zhu Z, Guggenheim JA, He M
Investigative ophthalmology & visual science · 2022 · PMID 35762941 · open access

Questions about rs1864009

What is rs1864009?

rs1864009 is a single position in the genome, in or near the near INSR gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1864009 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs1864009 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1864009 come from?

GWAS Catalog, Investigative ophthalmology & visual science 2022, PMID:35762941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systolic blood pressure (rs1864009). MyGeneLog™. https://www.mygenelog.com/variants/rs1864009

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