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Who was studied 2,270 African ancestry cases, 207,823 African ancestry controls.
The effect
Each copy of the T allele shifted the measure 1.21 higher (95% confidence interval 0.79-1.64); p = 2 × 10−8.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 20, band 20p11.21 — in an intron of SYNDIG1.
What each result means
C/CNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs186257749
What is rs186257749?
rs186257749 is a single position in the genome, in or near the SYNDIG1 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs186257749 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs186257749 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186257749 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 34118122118Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others18Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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