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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−25, with 5 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 408,112 British individuals.
The effect
Each copy of the G allele shifted the measure 0.0268 higher (95% confidence interval 0.022-0.032); p = 2 × 10−25.
How common The G allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 5, band 5q13.1 — in an intron of PIK3R1.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-26.
ClinVar record 1264402NM_181523.3(PIK3R1):c.917-3329A>G
Change history
MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Mean reticulocyte volume. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Mean reticulocyte volume. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Mean reticulocyte volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1862162 is a single position in the genome, in or near the PIK3R1 gene. Published research associates it with mean reticulocyte volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1862162 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1862162 come from?
GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mean reticulocyte volume (rs1862162). MyGeneLog™. https://www.mygenelog.com/variants/rs1862162