Standard
Gamma glutamyl transferase levels
DHRS9 · rs1862069
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 875,069 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0057 lower (95% confidence interval 0.0047-0.0067); p = 2 × 10−29.
Where it sits Chromosome 2, band 2q31.1 — in an intron of DHRS9.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Gamma glutamyl transferase levels — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gamma glutamyl transferase levels.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gamma glutamyl transferase levels compared to the general population.
Source
Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis
Ghouse J,
Sveinbjörnsson G,
Vujkovic M,
Seidelin AS,
Gellert-Kristensen H,
Ahlberg G,
Tragante V,
Rand SA,
Brancale J,
Vilarinho S,
Lundegaard PR,
Sørensen E
and 39 more — show all
Erikstrup C,
Bruun MT,
Jensen BA,
Brunak S,
Banasik K,
Ullum H,
Verweij N,
Lotta L,
Baras A,
Mirshahi T,
Carey DJ,
Kaplan DE,
Lynch J,
Morgan T,
Schwantes-An TH,
Dochtermann DR,
Pyarajan S,
Tsao PS,
Laisk T,
Mägi R,
Kozlitina J,
Tybjærg-Hansen A,
Jones D,
Knowlton KU,
Nadauld L,
Ferkingstad E,
Björnsson ES,
Ulfarsson MO,
Sturluson Á,
Sulem P,
Pedersen OB,
Ostrowski SR,
Gudbjartsson DF,
Stefansson K,
Olesen MS,
Chang KM,
Holm H,
Bundgaard H,
Stender S
Nature genetics · 2024 · PMID 38632349 · open access
Questions about rs1862069
What is rs1862069?
rs1862069 is a single position in the genome, in or near the DHRS9 gene. Published research associates it with gamma glutamyl transferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1862069 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1862069 come from?
GWAS Catalog, Nature genetics 2024, PMID:38632349. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Gamma glutamyl transferase levels (rs1862069). MyGeneLog™. https://www.mygenelog.com/variants/rs1862069
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