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Who was studied 164,454 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.233 higher (95% confidence interval 0.2-0.27); p = 1 × 10−39.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 18, band 18q22.2 — in an intron of RTTN.
What each result means
A/ATwo copies of the version the research linked to Mean platelet volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Mean platelet volume. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Mean platelet volume. This is the starting point the study compared everyone against.
rs185898 is a single position in the genome, in or near the RTTN gene. Published research associates it with mean platelet volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs185898 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs185898 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs185898 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2112315Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others15Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mean platelet volume (rs185898). MyGeneLog™. https://www.mygenelog.com/variants/rs185898