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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 677 African American or Afro-Caribbean cases, 121,041 African American or Afro-Caribbean controls, 711 European ancestry cases, 450,427 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 3.12 lower (95% confidence interval 3.1-3.15); p = 4 × 10−11.
How common The T allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 7, band 7q31.33 — between genes, 45.2 kb from POT1-AS1.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Hyperaldosteronism (PheCode 255.12) — no copies of the reported risk allele.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hyperaldosteronism (PheCode 255.12).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hyperaldosteronism (PheCode 255.12) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs185811454
What is rs185811454?
rs185811454 is a single position in the genome, in or near the near POT1-AS1 gene. Published research associates it with hyperaldosteronism (phecode 255.12). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs185811454 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs185811454 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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