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Takes medication for Crohn's disease?

near MGMT · rs185658725

Where this position leads

Condition: Crohn's Disease

rs185658725 Condition: Crohn's Disease Crohn's Disease Condition rs185658725 rs185658725 near MGMT

What the study found

Who was studied 388 African American or Afro-Caribbean cases, 55,117 African American or Afro-Caribbean controls, 1,952 European ancestry cases, 313,716 European ancestry controls.

The effect Each copy of the G allele shifted the measure 2.32 lower (95% confidence interval 2.27-2.37); p = 1 × 10−11.

How common The G allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 10, band 10q26.3 — between genes, 226.6 kb from MGMT.

What each result means

A/A No copy of the version the research linked to Takes medication for Crohn's disease?. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Takes medication for Crohn's disease?. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Takes medication for Crohn's disease?. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs185658725

What is rs185658725?

rs185658725 is a single position in the genome, in or near the near MGMT gene. Published research associates it with takes medication for crohn's disease?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs185658725 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs185658725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs185658725 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Takes medication for Crohn's disease? (rs185658725). MyGeneLog™. https://www.mygenelog.com/variants/rs185658725

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