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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 612 African American or Afro-Caribbean cases, 54,893 African American or Afro-Caribbean controls, 5,989 European ancestry cases, 309,679 European ancestry controls, 390 Hispanic or Latin American cases, 28,924 Hispanic or Latin American controls.
The effect
Each copy of the T allele shifted the measure 1.65 lower (95% confidence interval 1.58-1.73); p = 4 × 10−11.
How common The T allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 12, band 12q14.3 — in an intron of LEMD3.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Biological Grandparent (paternal): Cancer, Colon — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Biological Grandparent (paternal): Cancer, Colon.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Biological Grandparent (paternal): Cancer, Colon compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs184769708
What is rs184769708?
rs184769708 is a single position in the genome, in or near the LEMD3 gene. Published research associates it with biological grandparent (paternal): cancer, colon. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs184769708 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs184769708 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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