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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−12, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 663 African American or Afro-Caribbean cases, 120,221 African American or Afro-Caribbean controls, 2,283 European ancestry cases, 445,602 European ancestry controls, 224 Hispanic or Latin American cases, 59,309 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 2.27 lower (95% confidence interval 2.22-2.32); p = 4 × 10−13.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 9, band 9p21.1 — in an intron of LINGO2.
What each result means
A/ATwo copies of the version the research linked to Disorders of lacrimal system (PheCode 375). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Disorders of lacrimal system (PheCode 375). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Disorders of lacrimal system (PheCode 375). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs184726399
What is rs184726399?
rs184726399 is a single position in the genome, in or near the LINGO2 gene. Published research associates it with disorders of lacrimal system (phecode 375). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs184726399 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs184726399 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Disorders of lacrimal system (PheCode 375) (rs184726399). MyGeneLog™. https://www.mygenelog.com/variants/rs184726399