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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 900 African American or Afro-Caribbean cases, 119,648 African American or Afro-Caribbean controls, 3,149 European ancestry cases, 443,721 European ancestry controls, 483 Hispanic or Latin American cases, 58,765 Hispanic or Latin American controls.
The effect
Each copy of the T allele shifted the measure 3.75 lower (95% confidence interval 3.73-3.76); p = 3 × 10−13.
How common The T allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 10, band 10q24.32 — in an intron of TRIM8.
What each result means
C/CNo copy of the version the research linked to Pyelonephritis (PheCode 590). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Pyelonephritis (PheCode 590). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pyelonephritis (PheCode 590). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs184512262
What is rs184512262?
rs184512262 is a single position in the genome, in or near the TRIM8 gene. Published research associates it with pyelonephritis (phecode 590). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs184512262 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs184512262 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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