Malignant neoplasm of head, face, and neck (PheCode 195.3)
near RPL5P16 · rs183948737
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
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What the study found
Who was studied 492 African American or Afro-Caribbean cases, 121,151 African American or Afro-Caribbean controls, 4,578 European ancestry cases, 442,171 European ancestry controls, 233 Hispanic or Latin American cases, 59,498 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 1.77 lower (95% confidence interval 1.7-1.84); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 5, band 5q14.2 — between genes, 22.6 kb from RPL5P16.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Malignant neoplasm of head, face, and neck (PheCode 195.3) — no copies of the reported risk allele.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Malignant neoplasm of head, face, and neck (PheCode 195.3).
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Malignant neoplasm of head, face, and neck (PheCode 195.3) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs183948737
What is rs183948737?
rs183948737 is a single position in the genome, in or near the near RPL5P16 gene. Published research associates it with malignant neoplasm of head, face, and neck (phecode 195.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs183948737 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs183948737 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Malignant neoplasm of head, face, and neck (PheCode 195.3) (rs183948737). MyGeneLog™. https://www.mygenelog.com/variants/rs183948737