Gene Knowledge Graph UTC
Sensitive

Schizophrenia

PLCL1 · rs1837495

Where this position leads

Condition: Schizophrenia

rs1837495 Condition: Schizophrenia Schizophrenia Condition rs1837495 rs1837495 PLCL1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
Source
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect
Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T
and 20 more — show all
Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N
Schizophrenia bulletin · 2019 · PMID 30285260

Questions about rs1837495

What is rs1837495?

rs1837495 is a single position in the genome, in or near the PLCL1 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1837495 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs1837495 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1837495 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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