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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 43,148 European ancestry individuals; replicated in 1,179 Central or South Asian individuals, 1,161 African ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.974 lower (95% confidence interval 0.74-1.2); p = 1 × 10−16.
How common The C allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 20, band 20q11.23 — between genes, 1.2 kb from PPIAP3.
What each result means
C/CTwo copies of the version the research linked to Retinal thickness (pixel 67_162). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Retinal thickness (pixel 67_162). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Retinal thickness (pixel 67_162). This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 39904976 · open access
Questions about rs183659670
What is rs183659670?
rs183659670 is a single position in the genome, in or near the near PPIAP3 gene. Published research associates it with retinal thickness (pixel 67_162). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs183659670 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs183659670 come from?
GWAS Catalog, Nature communications 2025, PMID:39904976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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